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KMID : 0382320050250030104
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Environmental Mutagens and Carcinogens
2005 Volume.25 No. 3 p.104 ~ p.109
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Combined Effect of Radiation and 7β-Hydroxycholesterol on Human Cervical Cancer Cells in vitro
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Chae SW
Kang KA/Lee KH/Zhang R/Jung MS/Hyun JW
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Abstract
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7β-Hydroxycholesterol (cholest-5-ene-3, 7-diol, 7β-OHC) showed the cytotoxicity on human cervical carcinoma cells (HeLa), 10 μM of 50% inhibitory concentration. We evaluated 7β-OHC as the possibility of radiation sensitizer. The combination effect of 7β-OHC and γ-irradiation was measured using colony forming assay and flow cytometer with propidium iodide and DiOC_6 stained cells, respectively. The combined treatment of 7β-OHC and γ-irradiation did not show significant enhancing effects on HeLa cells.
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